Drug interactions
Hydralazine + Xipamide
Severity: Minor
Hydralazine and Xipamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Xipamide is a thiazide-like diuretic, and combining it with hydralazine lowers blood pressure more than either alone. This combination is often used intentionally, and the diuretic helps counter fluid retention from hydralazine. Hypotension and electrolyte disturbances may occur.
What this interaction means in plain words
Hydralazine and Xipamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive blood pressure lowering through diuresis-related volume reduction and direct arteriolar vasodilation.
What to do
Monitor blood pressure and serum electrolytes after starting or changing doses. Adjust doses to the blood pressure target.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydralazine
- Amifostine + Hydralazine Major
- Aceclofenac + Hydralazine Moderate
- Acemetacin + Hydralazine Moderate
- Aldesleukin + Hydralazine Moderate
- Avanafil + Hydralazine Moderate
- Benzphetamine + Hydralazine Moderate
Frequently asked questions
Can I take Hydralazine with Xipamide?
MediHelp rates the interaction as minor. Hydralazine and Xipamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Xipamide is a thiazide-like diuretic, and combining it with hydralazine lowers blood pressure more than either alone. This combination is often used intentionally, and the diuretic helps counter fluid retention from hydralazine. Hypotension and electrolyte disturbances may occur.
How serious is the interaction between Hydralazine and Xipamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and serum electrolytes after starting or changing doses. Adjust doses to the blood pressure target.
What other medicines interact with Hydralazine?
MediHelp also lists interactions of Hydralazine with, for example, Amifostine, Aceclofenac, Acemetacin. The full list is on the Hydralazine page.
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