Drug interactions
Hydralazine + Xylometazoline
Severity: Minor
Hydralazine and Xylometazoline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Xylometazoline is a vasoconstrictor that may raise blood pressure if enough is absorbed, opposing the effect of hydralazine. This is unlikely to matter with intranasal use at labeled doses, but could matter with overuse in patients with poorly controlled hypertension.
What this interaction means in plain words
Hydralazine and Xylometazoline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydralazine belongs to Cardiovascular; Xylometazoline belongs to Respiratory.
Why it happens
Pharmacodynamic antagonism between alpha-agonist vasoconstriction and the vasodilator effect of hydralazine.
What to do
Monitor blood pressure if the patient uses a decongestant regularly. Advise short-term use only.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Hydralazine and Xylometazoline, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Xylometazoline
- Selegiline + Xylometazoline Contraindicated
- Ergotamine + Xylometazoline Major
- Isocarboxazid + Xylometazoline Major
- Phenelzine + Xylometazoline Major
- Tranylcypromine + Xylometazoline Major
- Amitriptyline + Xylometazoline Moderate
Other interactions of Hydralazine
- Amifostine + Hydralazine Major
- Aceclofenac + Hydralazine Moderate
- Acemetacin + Hydralazine Moderate
- Aldesleukin + Hydralazine Moderate
- Avanafil + Hydralazine Moderate
- Benzphetamine + Hydralazine Moderate
Frequently asked questions
Can I take Hydralazine with Xylometazoline?
MediHelp rates the interaction as minor. Hydralazine and Xylometazoline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Xylometazoline is a vasoconstrictor that may raise blood pressure if enough is absorbed, opposing the effect of hydralazine. This is unlikely to matter with intranasal use at labeled doses, but could matter with overuse in patients with poorly controlled hypertension.
How serious is the interaction between Hydralazine and Xylometazoline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure if the patient uses a decongestant regularly. Advise short-term use only.
What other medicines interact with Xylometazoline?
MediHelp also lists interactions of Xylometazoline with, for example, Selegiline, Ergotamine, Isocarboxazid. The full list is on the Xylometazoline page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
