Drug interactions
Hydralazine + Yohimbine
Severity: Moderate
Hydralazine and Yohimbine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Yohimbine is an alpha-2 antagonist that typically increases sympathetic outflow and can raise blood pressure and heart rate, though effects vary. It may oppose the antihypertensive effect of hydralazine or cause unpredictable blood pressure swings. Tachycardia and anxiety may be amplified.
What this interaction means in plain words
Hydralazine and Yohimbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Alpha-2 adrenergic blockade increases norepinephrine release, which can oppose or destabilize the vasodilator effect of hydralazine.
What to do
Monitor blood pressure and heart rate during co-use. Avoid yohimbine in patients with poorly controlled hypertension.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydralazine
- Amifostine + Hydralazine Major
- Aceclofenac + Hydralazine Moderate
- Acemetacin + Hydralazine Moderate
- Aldesleukin + Hydralazine Moderate
- Avanafil + Hydralazine Moderate
- Benzphetamine + Hydralazine Moderate
Frequently asked questions
Can I take Hydralazine with Yohimbine?
MediHelp rates the interaction as moderate. Hydralazine and Yohimbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Yohimbine is an alpha-2 antagonist that typically increases sympathetic outflow and can raise blood pressure and heart rate, though effects vary. It may oppose the antihypertensive effect of hydralazine or cause unpredictable blood pressure swings. Tachycardia and anxiety may be amplified.
How serious is the interaction between Hydralazine and Yohimbine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate during co-use. Avoid yohimbine in patients with poorly controlled hypertension.
What other medicines interact with Hydralazine?
MediHelp also lists interactions of Hydralazine with, for example, Amifostine, Aceclofenac, Acemetacin. The full list is on the Hydralazine page.
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