Drug interactions
Hydrochlorothiazide-olmesartan + Insulin degludec
Severity: Moderate
Hydrochlorothiazide-olmesartan and Insulin degludec: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics can raise blood glucose and reduce the effectiveness of insulin in patients with diabetes. Olmesartan may offset this slightly by improving insulin sensitivity. Glycemic control can therefore change when the combination is started or stopped.
What this interaction means in plain words
Hydrochlorothiazide-olmesartan and Insulin degludec can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide-olmesartan belongs to Cardiovascular; Insulin degludec belongs to Endocrine.
Why it happens
Hydrochlorothiazide impairs glucose tolerance, partly via hypokalemia-related reduced insulin secretion and increased insulin resistance, opposing insulin action.
What to do
Monitor blood glucose after starting or adjusting the combination and titrate insulin degludec dose accordingly. Correct hypokalemia if present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-olmesartan
- Aliskiren + Hydrochlorothiazide-olmesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-olmesartan Contraindicated
- Hydrochlorothiazide-olmesartan + Sparsentan Contraindicated
- Acemetacin + Hydrochlorothiazide-olmesartan Major
- Amifostine + Hydrochlorothiazide-olmesartan Major
- Amiloride + Hydrochlorothiazide-olmesartan Major
Other interactions of Insulin degludec
Frequently asked questions
Can I take Hydrochlorothiazide-olmesartan with Insulin degludec?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-olmesartan and Insulin degludec can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazide diuretics can raise blood glucose and reduce the effectiveness of insulin in patients with diabetes. Olmesartan may offset this slightly by improving insulin sensitivity. Glycemic control can therefore change when the combination is started or stopped.
How serious is the interaction between Hydrochlorothiazide-olmesartan and Insulin degludec?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after starting or adjusting the combination and titrate insulin degludec dose accordingly. Correct hypokalemia if present.
What other medicines interact with Hydrochlorothiazide-olmesartan?
MediHelp also lists interactions of Hydrochlorothiazide-olmesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-olmesartan page.
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