Drug interactions
Hydrochlorothiazide-olmesartan + Insulin glulisine
Severity: Moderate
Hydrochlorothiazide-olmesartan and Insulin glulisine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Angiotensin receptor blockers can improve insulin sensitivity and may lower blood glucose in insulin-treated patients, occasionally causing hypoglycemia. Hydrochlorothiazide can raise glucose, so the net effect on control is variable.
What this interaction means in plain words
Hydrochlorothiazide-olmesartan and Insulin glulisine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide-olmesartan belongs to Cardiovascular; Insulin glulisine belongs to Endocrine.
Why it happens
Olmesartan may enhance insulin sensitivity while hydrochlorothiazide can impair glucose tolerance, producing opposing pharmacodynamic effects on glycemia.
What to do
Monitor blood glucose more frequently when starting, stopping or changing the combination. Adjust the insulin glulisine dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-olmesartan
- Aliskiren + Hydrochlorothiazide-olmesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-olmesartan Contraindicated
- Hydrochlorothiazide-olmesartan + Sparsentan Contraindicated
- Acemetacin + Hydrochlorothiazide-olmesartan Major
- Amifostine + Hydrochlorothiazide-olmesartan Major
- Amiloride + Hydrochlorothiazide-olmesartan Major
Other interactions of Insulin glulisine
Frequently asked questions
Can I take Hydrochlorothiazide-olmesartan with Insulin glulisine?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-olmesartan and Insulin glulisine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Angiotensin receptor blockers can improve insulin sensitivity and may lower blood glucose in insulin-treated patients, occasionally causing hypoglycemia. Hydrochlorothiazide can raise glucose, so the net effect on control is variable.
How serious is the interaction between Hydrochlorothiazide-olmesartan and Insulin glulisine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently when starting, stopping or changing the combination. Adjust the insulin glulisine dose as needed.
What other medicines interact with Hydrochlorothiazide-olmesartan?
MediHelp also lists interactions of Hydrochlorothiazide-olmesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-olmesartan page.
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