Drug interactions
Hydrochlorothiazide-olmesartan + Lofexidine
Severity: Moderate
Hydrochlorothiazide-olmesartan and Lofexidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lofexidine is a central alpha-2 agonist that lowers blood pressure and heart rate, and antihypertensives such as olmesartan and hydrochlorothiazide add to this. Combined use can cause symptomatic hypotension, dizziness and syncope.
What this interaction means in plain words
Hydrochlorothiazide-olmesartan and Lofexidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide-olmesartan belongs to Cardiovascular; Lofexidine belongs to Central Nervous System.
Why it happens
Additive blood pressure lowering from central sympatholytic action plus diuretic and angiotensin receptor blocking effects.
What to do
Monitor blood pressure and pulse during lofexidine therapy and counsel patients about orthostatic symptoms. Consider temporarily reducing antihypertensive doses if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-olmesartan
- Aliskiren + Hydrochlorothiazide-olmesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-olmesartan Contraindicated
- Hydrochlorothiazide-olmesartan + Sparsentan Contraindicated
- Acemetacin + Hydrochlorothiazide-olmesartan Major
- Amifostine + Hydrochlorothiazide-olmesartan Major
- Amiloride + Hydrochlorothiazide-olmesartan Major
Other interactions of Lofexidine
- Adagrasib + Lofexidine Major
- Alfuzosin + Lofexidine Major
- Amiodarone + Lofexidine Major
- Amisulpride + Lofexidine Major
- Anagrelide + Lofexidine Major
- Apomorphine + Lofexidine Major
Frequently asked questions
Can I take Hydrochlorothiazide-olmesartan with Lofexidine?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-olmesartan and Lofexidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lofexidine is a central alpha-2 agonist that lowers blood pressure and heart rate, and antihypertensives such as olmesartan and hydrochlorothiazide add to this. Combined use can cause symptomatic hypotension, dizziness and syncope.
How serious is the interaction between Hydrochlorothiazide-olmesartan and Lofexidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and pulse during lofexidine therapy and counsel patients about orthostatic symptoms. Consider temporarily reducing antihypertensive doses if hypotension occurs.
What other medicines interact with Hydrochlorothiazide-olmesartan?
MediHelp also lists interactions of Hydrochlorothiazide-olmesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-olmesartan page.
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