Drug interactions
Hydrochlorothiazide-olmesartan + Magnesium citrate
Severity: Minor
Hydrochlorothiazide-olmesartan and Magnesium citrate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics increase urinary magnesium loss and can lower serum magnesium during long-term use. Occasional magnesium supplementation may offset this, so the interaction is generally of limited concern.
What this interaction means in plain words
Hydrochlorothiazide-olmesartan and Magnesium citrate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrochlorothiazide-olmesartan belongs to Cardiovascular; Magnesium citrate belongs to Gastrointestinal Tract.
Why it happens
Thiazides increase renal magnesium excretion, opposing magnesium supplementation.
What to do
Monitor serum magnesium in at-risk patients and adjust supplementation if hypomagnesemia persists.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-olmesartan
- Aliskiren + Hydrochlorothiazide-olmesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-olmesartan Contraindicated
- Hydrochlorothiazide-olmesartan + Sparsentan Contraindicated
- Acemetacin + Hydrochlorothiazide-olmesartan Major
- Amifostine + Hydrochlorothiazide-olmesartan Major
- Amiloride + Hydrochlorothiazide-olmesartan Major
Other interactions of Magnesium citrate
- Ciprofloxacin + Magnesium citrate Major
- Baloxavir marboxil + Magnesium citrate Moderate
- Bictegravir + Magnesium citrate Moderate
- Cabotegravir + Magnesium citrate Moderate
- Cholecalciferol + Magnesium citrate Moderate
- Deferiprone + Magnesium citrate Moderate
Frequently asked questions
Can I take Hydrochlorothiazide-olmesartan with Magnesium citrate?
MediHelp rates the interaction as minor. Hydrochlorothiazide-olmesartan and Magnesium citrate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Thiazide diuretics increase urinary magnesium loss and can lower serum magnesium during long-term use. Occasional magnesium supplementation may offset this, so the interaction is generally of limited concern.
How serious is the interaction between Hydrochlorothiazide-olmesartan and Magnesium citrate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum magnesium in at-risk patients and adjust supplementation if hypomagnesemia persists.
What other medicines interact with Hydrochlorothiazide-olmesartan?
MediHelp also lists interactions of Hydrochlorothiazide-olmesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-olmesartan page.
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