Drug interactions
Hydrochlorothiazide-olmesartan + Ofloxacin
Severity: Minor
Hydrochlorothiazide-olmesartan and Ofloxacin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are eliminated partly by renal tubular secretion, so ofloxacin levels could rise slightly. Clinical significance is minimal in most patients, though electrolyte disturbance from the diuretic could add to QT concerns.
What this interaction means in plain words
Hydrochlorothiazide-olmesartan and Ofloxacin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrochlorothiazide-olmesartan belongs to Cardiovascular; Ofloxacin belongs to Anti Bacterial.
Why it happens
Possible competition for renal tubular secretion; diuretic-induced hypokalemia may add to fluoroquinolone QT effects.
What to do
No routine change; correct hypokalemia or hypomagnesemia and consider renal function when dosing ofloxacin.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-olmesartan
- Aliskiren + Hydrochlorothiazide-olmesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-olmesartan Contraindicated
- Hydrochlorothiazide-olmesartan + Sparsentan Contraindicated
- Acemetacin + Hydrochlorothiazide-olmesartan Major
- Amifostine + Hydrochlorothiazide-olmesartan Major
- Amiloride + Hydrochlorothiazide-olmesartan Major
Other interactions of Ofloxacin
- Ofloxacin + Thioridazine Contraindicated
- Adagrasib + Ofloxacin Major
- Amiodarone + Ofloxacin Major
- Amisulpride + Ofloxacin Major
- Anagrelide + Ofloxacin Major
- Arsenic trioxide + Ofloxacin Major
Frequently asked questions
Can I take Hydrochlorothiazide-olmesartan with Ofloxacin?
MediHelp rates the interaction as minor. Hydrochlorothiazide-olmesartan and Ofloxacin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs are eliminated partly by renal tubular secretion, so ofloxacin levels could rise slightly. Clinical significance is minimal in most patients, though electrolyte disturbance from the diuretic could add to QT concerns.
How serious is the interaction between Hydrochlorothiazide-olmesartan and Ofloxacin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change; correct hypokalemia or hypomagnesemia and consider renal function when dosing ofloxacin.
What other medicines interact with Hydrochlorothiazide-olmesartan?
MediHelp also lists interactions of Hydrochlorothiazide-olmesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-olmesartan page.
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