Drug interactions
Hydrochlorothiazide-olmesartan + Patiromer
Severity: Minor
Hydrochlorothiazide-olmesartan and Patiromer: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Patiromer binds cations in the gut and could theoretically reduce absorption of some oral drugs. Studies with olmesartan, and with several other drugs, showed no clinically important interaction.
What this interaction means in plain words
Hydrochlorothiazide-olmesartan and Patiromer have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrochlorothiazide-olmesartan belongs to Cardiovascular; Patiromer belongs to Miscellaneous.
Why it happens
Possible gut binding by patiromer, not shown to be clinically relevant for olmesartan.
What to do
No dose separation is required for olmesartan; label advice to separate other oral drugs by 3 hours is a reasonable precaution for hydrochlorothiazide.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-olmesartan
- Aliskiren + Hydrochlorothiazide-olmesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-olmesartan Contraindicated
- Hydrochlorothiazide-olmesartan + Sparsentan Contraindicated
- Acemetacin + Hydrochlorothiazide-olmesartan Major
- Amifostine + Hydrochlorothiazide-olmesartan Major
- Amiloride + Hydrochlorothiazide-olmesartan Major
Other interactions of Patiromer
- Alogliptin-metformin + Patiromer Moderate
- Canagliflozin-metformin + Patiromer Moderate
- Carvedilol + Patiromer Moderate
- Ciprofloxacin + Patiromer Moderate
- Dapagliflozin-metformin + Patiromer Moderate
- Empagliflozin-metformin + Patiromer Moderate
Frequently asked questions
Can I take Hydrochlorothiazide-olmesartan with Patiromer?
MediHelp rates the interaction as minor. Hydrochlorothiazide-olmesartan and Patiromer have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Patiromer binds cations in the gut and could theoretically reduce absorption of some oral drugs. Studies with olmesartan, and with several other drugs, showed no clinically important interaction.
How serious is the interaction between Hydrochlorothiazide-olmesartan and Patiromer?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose separation is required for olmesartan; label advice to separate other oral drugs by 3 hours is a reasonable precaution for hydrochlorothiazide.
What other medicines interact with Hydrochlorothiazide-olmesartan?
MediHelp also lists interactions of Hydrochlorothiazide-olmesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-olmesartan page.
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