Drug interactions
Dapagliflozin-metformin + Patiromer
Severity: Moderate
Dapagliflozin-metformin and Patiromer: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Patiromer is a non-absorbed polymer that can bind coadministered oral drugs in the gut. This may lower metformin absorption and reduce glycemic control.
What this interaction means in plain words
Dapagliflozin-metformin and Patiromer can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dapagliflozin-metformin belongs to Endocrine; Patiromer belongs to Miscellaneous.
Why it happens
Patiromer binds metformin in the gastrointestinal tract, reducing its absorption.
What to do
Take metformin at least 3 hours before or 3 hours after patiromer. Monitor glucose control if dosing schedules overlap.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dapagliflozin-metformin
Other interactions of Patiromer
- Alogliptin-metformin + Patiromer Moderate
- Canagliflozin-metformin + Patiromer Moderate
- Carvedilol + Patiromer Moderate
- Ciprofloxacin + Patiromer Moderate
- Empagliflozin-metformin + Patiromer Moderate
- Glipizide-metformin + Patiromer Moderate
Frequently asked questions
Can I take Dapagliflozin-metformin with Patiromer?
MediHelp rates the interaction as moderate. Dapagliflozin-metformin and Patiromer can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Patiromer is a non-absorbed polymer that can bind coadministered oral drugs in the gut. This may lower metformin absorption and reduce glycemic control.
How serious is the interaction between Dapagliflozin-metformin and Patiromer?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Take metformin at least 3 hours before or 3 hours after patiromer. Monitor glucose control if dosing schedules overlap.
What other medicines interact with Dapagliflozin-metformin?
MediHelp also lists interactions of Dapagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Dapagliflozin-metformin page.
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