Drug interactions
Hydrochlorothiazide-olmesartan + Pioglitazone
Severity: Minor
Hydrochlorothiazide-olmesartan and Pioglitazone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics can raise blood glucose and may reduce the glucose-lowering effect of pioglitazone. The effect is usually modest at low hydrochlorothiazide doses.
What this interaction means in plain words
Hydrochlorothiazide-olmesartan and Pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrochlorothiazide-olmesartan belongs to Cardiovascular; Pioglitazone belongs to Endocrine.
Why it happens
Thiazides reduce insulin secretion and sensitivity, opposing pioglitazone.
What to do
Monitor blood glucose and HbA1c and adjust diabetes therapy if control worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-olmesartan
- Aliskiren + Hydrochlorothiazide-olmesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-olmesartan Contraindicated
- Hydrochlorothiazide-olmesartan + Sparsentan Contraindicated
- Acemetacin + Hydrochlorothiazide-olmesartan Major
- Amifostine + Hydrochlorothiazide-olmesartan Major
- Amiloride + Hydrochlorothiazide-olmesartan Major
Other interactions of Pioglitazone
Frequently asked questions
Can I take Hydrochlorothiazide-olmesartan with Pioglitazone?
MediHelp rates the interaction as minor. Hydrochlorothiazide-olmesartan and Pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Thiazide diuretics can raise blood glucose and may reduce the glucose-lowering effect of pioglitazone. The effect is usually modest at low hydrochlorothiazide doses.
How serious is the interaction between Hydrochlorothiazide-olmesartan and Pioglitazone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c and adjust diabetes therapy if control worsens.
What other medicines interact with Hydrochlorothiazide-olmesartan?
MediHelp also lists interactions of Hydrochlorothiazide-olmesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-olmesartan page.
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