Drug interactions
Hydrochlorothiazide-olmesartan + Quinine
Severity: Moderate
Hydrochlorothiazide-olmesartan and Quinine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinine can prolong the QT interval, and thiazide-induced hypokalemia or hypomagnesemia increases the risk of arrhythmia. A renal clearance interaction is theoretical.
What this interaction means in plain words
Hydrochlorothiazide-olmesartan and Quinine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide-olmesartan belongs to Cardiovascular; Quinine belongs to Anti Parasitic.
Why it happens
Diuretic-induced electrolyte depletion potentiates quinine QT prolongation; possible competition for renal tubular cation secretion.
What to do
Check and correct potassium and magnesium before and during quinine therapy, and consider ECG monitoring in patients with other QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-olmesartan
- Aliskiren + Hydrochlorothiazide-olmesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-olmesartan Contraindicated
- Hydrochlorothiazide-olmesartan + Sparsentan Contraindicated
- Acemetacin + Hydrochlorothiazide-olmesartan Major
- Amifostine + Hydrochlorothiazide-olmesartan Major
- Amiloride + Hydrochlorothiazide-olmesartan Major
Other interactions of Quinine
- Arsenic trioxide + Quinine Contraindicated
- Dofetilide + Quinine Contraindicated
- Dronedarone + Quinine Contraindicated
- Ibutilide + Quinine Contraindicated
- Mefloquine + Quinine Contraindicated
- Nilotinib + Quinine Contraindicated
Frequently asked questions
Can I take Hydrochlorothiazide-olmesartan with Quinine?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-olmesartan and Quinine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quinine can prolong the QT interval, and thiazide-induced hypokalemia or hypomagnesemia increases the risk of arrhythmia. A renal clearance interaction is theoretical.
How serious is the interaction between Hydrochlorothiazide-olmesartan and Quinine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check and correct potassium and magnesium before and during quinine therapy, and consider ECG monitoring in patients with other QT risk factors.
What other medicines interact with Hydrochlorothiazide-olmesartan?
MediHelp also lists interactions of Hydrochlorothiazide-olmesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-olmesartan page.
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