Drug interactions
Hydrochlorothiazide-olmesartan + Salmeterol
Severity: Moderate
Hydrochlorothiazide-olmesartan and Salmeterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both hydrochlorothiazide and salmeterol can lower serum potassium, so hypokalemia may be more pronounced. This is mainly relevant with high doses or in patients with other risk factors for arrhythmia.
What this interaction means in plain words
Hydrochlorothiazide-olmesartan and Salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide-olmesartan belongs to Cardiovascular; Salmeterol belongs to Respiratory.
Why it happens
Additive hypokalemia through thiazide renal potassium loss and beta-2 agonist intracellular potassium shift.
What to do
Monitor serum potassium, especially in severe asthma or COPD or with hypoxia. Replace potassium or magnesium if low.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-olmesartan
- Aliskiren + Hydrochlorothiazide-olmesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-olmesartan Contraindicated
- Hydrochlorothiazide-olmesartan + Sparsentan Contraindicated
- Acemetacin + Hydrochlorothiazide-olmesartan Major
- Amifostine + Hydrochlorothiazide-olmesartan Major
- Amiloride + Hydrochlorothiazide-olmesartan Major
Other interactions of Salmeterol
- Ritonavir + Salmeterol Contraindicated
- Salmeterol + Saquinavir Contraindicated
- Amitriptyline + Salmeterol Major
- Arformoterol + Salmeterol Major
- Atazanavir + Salmeterol Major
- Budesonide-formoterol + Salmeterol Major
Frequently asked questions
Can I take Hydrochlorothiazide-olmesartan with Salmeterol?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-olmesartan and Salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both hydrochlorothiazide and salmeterol can lower serum potassium, so hypokalemia may be more pronounced. This is mainly relevant with high doses or in patients with other risk factors for arrhythmia.
How serious is the interaction between Hydrochlorothiazide-olmesartan and Salmeterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium, especially in severe asthma or COPD or with hypoxia. Replace potassium or magnesium if low.
What other medicines interact with Hydrochlorothiazide-olmesartan?
MediHelp also lists interactions of Hydrochlorothiazide-olmesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-olmesartan page.
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