Drug interactions
Hydrochlorothiazide-olmesartan + Tadalafil
Severity: Moderate
Hydrochlorothiazide-olmesartan and Tadalafil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tadalafil has vasodilating properties and may add to the blood pressure lowering of olmesartan and hydrochlorothiazide. Symptomatic hypotension can occur, particularly at treatment initiation or in volume-depleted patients.
What this interaction means in plain words
Hydrochlorothiazide-olmesartan and Tadalafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide-olmesartan belongs to Cardiovascular; Tadalafil belongs to Genitourinary.
Why it happens
Additive vasodilation from PDE5 inhibition and antihypertensive therapy.
What to do
Start tadalafil at a low dose and counsel on orthostatic symptoms. Monitor blood pressure, and ensure the patient is hemodynamically stable.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-olmesartan
- Aliskiren + Hydrochlorothiazide-olmesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-olmesartan Contraindicated
- Hydrochlorothiazide-olmesartan + Sparsentan Contraindicated
- Acemetacin + Hydrochlorothiazide-olmesartan Major
- Amifostine + Hydrochlorothiazide-olmesartan Major
- Amiloride + Hydrochlorothiazide-olmesartan Major
Other interactions of Tadalafil
- Amyl nitrite + Tadalafil Contraindicated
- Isosorbide dinitrate + Tadalafil Contraindicated
- Isosorbide mononitrate + Tadalafil Contraindicated
- Nitroglycerin po + Tadalafil Contraindicated
- Nitroglycerin rectal + Tadalafil Contraindicated
- Nitroglycerin sublingual + Tadalafil Contraindicated
Frequently asked questions
Can I take Hydrochlorothiazide-olmesartan with Tadalafil?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-olmesartan and Tadalafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tadalafil has vasodilating properties and may add to the blood pressure lowering of olmesartan and hydrochlorothiazide. Symptomatic hypotension can occur, particularly at treatment initiation or in volume-depleted patients.
How serious is the interaction between Hydrochlorothiazide-olmesartan and Tadalafil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start tadalafil at a low dose and counsel on orthostatic symptoms. Monitor blood pressure, and ensure the patient is hemodynamically stable.
What other medicines interact with Hydrochlorothiazide-olmesartan?
MediHelp also lists interactions of Hydrochlorothiazide-olmesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-olmesartan page.
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