Drug interactions
Hydrochlorothiazide-olmesartan + Timolol
Severity: Minor
Hydrochlorothiazide-olmesartan and Timolol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic timolol, including absorption from eye drops, can add to the blood pressure lowering of olmesartan and hydrochlorothiazide, with possible bradycardia or hypotension. Beta-blockade may slightly raise potassium.
What this interaction means in plain words
Hydrochlorothiazide-olmesartan and Timolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrochlorothiazide-olmesartan belongs to Cardiovascular; Timolol belongs to Cardiovascular.
Why it happens
Additive antihypertensive pharmacodynamic effects and minor potassium-raising effect of beta-blockade.
What to do
Monitor blood pressure and heart rate when starting or adjusting timolol. Check potassium periodically if renal function is impaired.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-olmesartan
- Aliskiren + Hydrochlorothiazide-olmesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-olmesartan Contraindicated
- Hydrochlorothiazide-olmesartan + Sparsentan Contraindicated
- Acemetacin + Hydrochlorothiazide-olmesartan Major
- Amifostine + Hydrochlorothiazide-olmesartan Major
- Amiloride + Hydrochlorothiazide-olmesartan Major
Other interactions of Timolol
- Acebutolol + Timolol Major
- Albuterol + Timolol Major
- Aldesleukin + Timolol Major
- Amifostine + Timolol Major
- Amiodarone + Timolol Major
- Arformoterol + Timolol Major
Frequently asked questions
Can I take Hydrochlorothiazide-olmesartan with Timolol?
MediHelp rates the interaction as minor. Hydrochlorothiazide-olmesartan and Timolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Systemic timolol, including absorption from eye drops, can add to the blood pressure lowering of olmesartan and hydrochlorothiazide, with possible bradycardia or hypotension. Beta-blockade may slightly raise potassium.
How serious is the interaction between Hydrochlorothiazide-olmesartan and Timolol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when starting or adjusting timolol. Check potassium periodically if renal function is impaired.
What other medicines interact with Hydrochlorothiazide-olmesartan?
MediHelp also lists interactions of Hydrochlorothiazide-olmesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-olmesartan page.
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