Drug interactions
Hydrochlorothiazide-olmesartan + Triamterene
Severity: Major
Hydrochlorothiazide-olmesartan and Triamterene: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Triamterene is a potassium-sparing diuretic and, with olmesartan, can cause clinically significant hyperkalemia. Risk is higher with renal impairment, diabetes and older age.
What this interaction means in plain words
Hydrochlorothiazide-olmesartan and Triamterene can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Hydrochlorothiazide-olmesartan belongs to Cardiovascular; Triamterene belongs to Cardiovascular.
Why it happens
Triamterene blocks epithelial sodium channels and olmesartan reduces aldosterone effect, additively reducing potassium excretion.
What to do
Monitor serum potassium and renal function closely and avoid potassium supplements. Stop triamterene if hyperkalemia develops.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Hydrochlorothiazide-olmesartan
- Aliskiren + Hydrochlorothiazide-olmesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-olmesartan Contraindicated
- Hydrochlorothiazide-olmesartan + Sparsentan Contraindicated
- Acemetacin + Hydrochlorothiazide-olmesartan Major
- Amifostine + Hydrochlorothiazide-olmesartan Major
- Amiloride + Hydrochlorothiazide-olmesartan Major
Other interactions of Triamterene
- Amiloride + Triamterene Contraindicated
- Eplerenone + Triamterene Contraindicated
- Potassium citrate / citric acid + Triamterene Contraindicated
- Potassium citrate + Triamterene Contraindicated
- Spironolactone + Triamterene Contraindicated
- Aceclofenac + Triamterene Major
Frequently asked questions
Can I take Hydrochlorothiazide-olmesartan with Triamterene?
MediHelp rates the interaction as major. Hydrochlorothiazide-olmesartan and Triamterene can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Triamterene is a potassium-sparing diuretic and, with olmesartan, can cause clinically significant hyperkalemia. Risk is higher with renal impairment, diabetes and older age.
How serious is the interaction between Hydrochlorothiazide-olmesartan and Triamterene?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and renal function closely and avoid potassium supplements. Stop triamterene if hyperkalemia develops.
What other medicines interact with Hydrochlorothiazide-olmesartan?
MediHelp also lists interactions of Hydrochlorothiazide-olmesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-olmesartan page.
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