Drug interactions
Hydrochlorothiazide-telmisartan + Indacaterol inhaled
Severity: Moderate
Hydrochlorothiazide-telmisartan and Indacaterol inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indacaterol, a long-acting beta-2 agonist, can lower serum potassium, and thiazide diuretics also cause potassium loss. Together hypokalemia may be more pronounced and may predispose to arrhythmias, particularly in patients with hypoxia.
What this interaction means in plain words
Hydrochlorothiazide-telmisartan and Indacaterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Beta-2 mediated intracellular potassium shift is additive to thiazide-induced renal potassium loss.
What to do
Monitor serum potassium, especially at initiation and in patients with severe COPD or other risk factors. Correct hypokalemia, and note that telmisartan may partly offset the potassium loss.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-telmisartan
- Aliskiren + Hydrochlorothiazide-telmisartan Contraindicated
- Dofetilide + Hydrochlorothiazide-telmisartan Contraindicated
- Hydrochlorothiazide-telmisartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-telmisartan Major
- Amifostine + Hydrochlorothiazide-telmisartan Major
- Amiloride + Hydrochlorothiazide-telmisartan Major
Frequently asked questions
Can I take Hydrochlorothiazide-telmisartan with Indacaterol inhaled?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-telmisartan and Indacaterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indacaterol, a long-acting beta-2 agonist, can lower serum potassium, and thiazide diuretics also cause potassium loss. Together hypokalemia may be more pronounced and may predispose to arrhythmias, particularly in patients with hypoxia.
How serious is the interaction between Hydrochlorothiazide-telmisartan and Indacaterol inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium, especially at initiation and in patients with severe COPD or other risk factors. Correct hypokalemia, and note that telmisartan may partly offset the potassium loss.
What other medicines interact with Hydrochlorothiazide-telmisartan?
MediHelp also lists interactions of Hydrochlorothiazide-telmisartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-telmisartan page.
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