Drug interactions
Hydrochlorothiazide-telmisartan + Indapamide
Severity: Moderate
Hydrochlorothiazide-telmisartan and Indapamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indapamide is a thiazide-like diuretic, so adding it to a product that already contains hydrochlorothiazide duplicates diuretic therapy. This increases the risk of hyponatremia, hypokalemia, volume depletion and hypotension, though telmisartan partly offsets potassium loss.
What this interaction means in plain words
Hydrochlorothiazide-telmisartan and Indapamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide-telmisartan belongs to Cardiovascular; Indapamide belongs to Cardiovascular.
Why it happens
Two thiazide-type diuretics inhibit the same sodium-chloride cotransporter, producing additive natriuresis and electrolyte loss.
What to do
Avoid concurrent use of two thiazide-type agents. If needed, monitor sodium, potassium, creatinine and blood pressure closely.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-telmisartan
- Aliskiren + Hydrochlorothiazide-telmisartan Contraindicated
- Dofetilide + Hydrochlorothiazide-telmisartan Contraindicated
- Hydrochlorothiazide-telmisartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-telmisartan Major
- Amifostine + Hydrochlorothiazide-telmisartan Major
- Amiloride + Hydrochlorothiazide-telmisartan Major
Other interactions of Indapamide
Frequently asked questions
Can I take Hydrochlorothiazide-telmisartan with Indapamide?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-telmisartan and Indapamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indapamide is a thiazide-like diuretic, so adding it to a product that already contains hydrochlorothiazide duplicates diuretic therapy. This increases the risk of hyponatremia, hypokalemia, volume depletion and hypotension, though telmisartan partly offsets potassium loss.
How serious is the interaction between Hydrochlorothiazide-telmisartan and Indapamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use of two thiazide-type agents. If needed, monitor sodium, potassium, creatinine and blood pressure closely.
What other medicines interact with Hydrochlorothiazide-telmisartan?
MediHelp also lists interactions of Hydrochlorothiazide-telmisartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-telmisartan page.
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