Drug interactions
Hydrochlorothiazide-telmisartan + Insulin aspart protamine / insulin aspart
Severity: Moderate
Hydrochlorothiazide-telmisartan and Insulin aspart protamine / insulin aspart: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Telmisartan may improve insulin sensitivity and increase the glucose-lowering effect of insulin, raising hypoglycemia risk. Hydrochlorothiazide, however, can worsen glucose control, so the net effect varies between patients.
What this interaction means in plain words
Hydrochlorothiazide-telmisartan and Insulin aspart protamine / insulin aspart can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
ARBs may enhance insulin sensitivity, whereas thiazides impair glucose tolerance, giving variable pharmacodynamic effects on glycemia.
What to do
Monitor blood glucose more often when starting or changing the combination. Adjust the insulin dose to glucose readings.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-telmisartan
- Aliskiren + Hydrochlorothiazide-telmisartan Contraindicated
- Dofetilide + Hydrochlorothiazide-telmisartan Contraindicated
- Hydrochlorothiazide-telmisartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-telmisartan Major
- Amifostine + Hydrochlorothiazide-telmisartan Major
- Amiloride + Hydrochlorothiazide-telmisartan Major
Frequently asked questions
Can I take Hydrochlorothiazide-telmisartan with Insulin aspart protamine / insulin aspart?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-telmisartan and Insulin aspart protamine / insulin aspart can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Telmisartan may improve insulin sensitivity and increase the glucose-lowering effect of insulin, raising hypoglycemia risk. Hydrochlorothiazide, however, can worsen glucose control, so the net effect varies between patients.
How serious is the interaction between Hydrochlorothiazide-telmisartan and Insulin aspart protamine / insulin aspart?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more often when starting or changing the combination. Adjust the insulin dose to glucose readings.
What other medicines interact with Hydrochlorothiazide-telmisartan?
MediHelp also lists interactions of Hydrochlorothiazide-telmisartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-telmisartan page.
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