Drug interactions
Hydrochlorothiazide-telmisartan + Insulin degludec / insulin aspart
Severity: Moderate
Hydrochlorothiazide-telmisartan and Insulin degludec / insulin aspart: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Telmisartan may enhance the glucose-lowering effect of insulin, while hydrochlorothiazide can raise blood glucose and reduce insulin effectiveness. Glycemic control may therefore change after the combination is started or modified.
What this interaction means in plain words
Hydrochlorothiazide-telmisartan and Insulin degludec / insulin aspart can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
ARBs may improve insulin sensitivity while thiazides impair glucose tolerance, partly through hypokalemia-related reduced insulin secretion.
What to do
Monitor blood glucose closely when starting, stopping or changing doses and adjust insulin accordingly. Keep serum potassium in the normal range.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-telmisartan
- Aliskiren + Hydrochlorothiazide-telmisartan Contraindicated
- Dofetilide + Hydrochlorothiazide-telmisartan Contraindicated
- Hydrochlorothiazide-telmisartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-telmisartan Major
- Amifostine + Hydrochlorothiazide-telmisartan Major
- Amiloride + Hydrochlorothiazide-telmisartan Major
Frequently asked questions
Can I take Hydrochlorothiazide-telmisartan with Insulin degludec / insulin aspart?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-telmisartan and Insulin degludec / insulin aspart can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Telmisartan may enhance the glucose-lowering effect of insulin, while hydrochlorothiazide can raise blood glucose and reduce insulin effectiveness. Glycemic control may therefore change after the combination is started or modified.
How serious is the interaction between Hydrochlorothiazide-telmisartan and Insulin degludec / insulin aspart?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely when starting, stopping or changing doses and adjust insulin accordingly. Keep serum potassium in the normal range.
What other medicines interact with Hydrochlorothiazide-telmisartan?
MediHelp also lists interactions of Hydrochlorothiazide-telmisartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-telmisartan page.
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