Drug interactions
Hydrochlorothiazide-telmisartan + Insulin lispro protamine / insulin lispro
Severity: Moderate
Hydrochlorothiazide-telmisartan and Insulin lispro protamine / insulin lispro: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Telmisartan may improve insulin sensitivity and increase the glucose-lowering effect of insulin, raising hypoglycemia risk. Hydrochlorothiazide can raise glucose, so the net effect on control differs between patients.
What this interaction means in plain words
Hydrochlorothiazide-telmisartan and Insulin lispro protamine / insulin lispro can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
ARBs may enhance insulin sensitivity while thiazides impair glucose tolerance, giving variable pharmacodynamic effects on glycemia.
What to do
Monitor blood glucose more frequently when starting or adjusting therapy. Adjust the insulin dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Hydrochlorothiazide-telmisartan and Insulin lispro protamine / insulin lispro, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Hydrochlorothiazide-telmisartan
- Aliskiren + Hydrochlorothiazide-telmisartan Contraindicated
- Dofetilide + Hydrochlorothiazide-telmisartan Contraindicated
- Hydrochlorothiazide-telmisartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-telmisartan Major
- Amifostine + Hydrochlorothiazide-telmisartan Major
- Amiloride + Hydrochlorothiazide-telmisartan Major
Frequently asked questions
Can I take Hydrochlorothiazide-telmisartan with Insulin lispro protamine / insulin lispro?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-telmisartan and Insulin lispro protamine / insulin lispro can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Telmisartan may improve insulin sensitivity and increase the glucose-lowering effect of insulin, raising hypoglycemia risk. Hydrochlorothiazide can raise glucose, so the net effect on control differs between patients.
How serious is the interaction between Hydrochlorothiazide-telmisartan and Insulin lispro protamine / insulin lispro?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently when starting or adjusting therapy. Adjust the insulin dose as needed.
What other medicines interact with Hydrochlorothiazide-telmisartan?
MediHelp also lists interactions of Hydrochlorothiazide-telmisartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-telmisartan page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
