Drug interactions
Hydrochlorothiazide-telmisartan + Metaproterenol
Severity: Moderate
Hydrochlorothiazide-telmisartan and Metaproterenol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metaproterenol can lower serum potassium through intracellular shift, and hydrochlorothiazide causes renal potassium loss. The combination may produce significant hypokalemia and arrhythmia risk, especially with high doses.
What this interaction means in plain words
Hydrochlorothiazide-telmisartan and Metaproterenol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypokalemia from beta-2 stimulated cellular potassium uptake plus thiazide-induced urinary potassium loss.
What to do
Monitor serum potassium in patients using frequent or high-dose metaproterenol, and replace potassium if low.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-telmisartan
- Aliskiren + Hydrochlorothiazide-telmisartan Contraindicated
- Dofetilide + Hydrochlorothiazide-telmisartan Contraindicated
- Hydrochlorothiazide-telmisartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-telmisartan Major
- Amifostine + Hydrochlorothiazide-telmisartan Major
- Amiloride + Hydrochlorothiazide-telmisartan Major
Frequently asked questions
Can I take Hydrochlorothiazide-telmisartan with Metaproterenol?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-telmisartan and Metaproterenol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metaproterenol can lower serum potassium through intracellular shift, and hydrochlorothiazide causes renal potassium loss. The combination may produce significant hypokalemia and arrhythmia risk, especially with high doses.
How serious is the interaction between Hydrochlorothiazide-telmisartan and Metaproterenol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium in patients using frequent or high-dose metaproterenol, and replace potassium if low.
What other medicines interact with Hydrochlorothiazide-telmisartan?
MediHelp also lists interactions of Hydrochlorothiazide-telmisartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-telmisartan page.
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