Drug interactions
Hydrochlorothiazide-telmisartan + Metformin
Severity: Moderate
Hydrochlorothiazide-telmisartan and Metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazides can raise blood glucose and may reduce the glucose-lowering effect of metformin. Diuretic-related volume depletion and reduced renal function may also raise metformin levels and the risk of lactic acidosis.
What this interaction means in plain words
Hydrochlorothiazide-telmisartan and Metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide-telmisartan belongs to Cardiovascular; Metformin belongs to Endocrine.
Why it happens
Thiazides impair glucose tolerance (pharmacodynamic antagonism) and may reduce renal metformin clearance through volume depletion or tubular competition.
What to do
Monitor blood glucose and HbA1c and adjust antidiabetic therapy as needed. Check renal function regularly and reassess metformin if eGFR falls or dehydration occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-telmisartan
- Aliskiren + Hydrochlorothiazide-telmisartan Contraindicated
- Dofetilide + Hydrochlorothiazide-telmisartan Contraindicated
- Hydrochlorothiazide-telmisartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-telmisartan Major
- Amifostine + Hydrochlorothiazide-telmisartan Major
- Amiloride + Hydrochlorothiazide-telmisartan Major
Other interactions of Metformin
Frequently asked questions
Can I take Hydrochlorothiazide-telmisartan with Metformin?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-telmisartan and Metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazides can raise blood glucose and may reduce the glucose-lowering effect of metformin. Diuretic-related volume depletion and reduced renal function may also raise metformin levels and the risk of lactic acidosis.
How serious is the interaction between Hydrochlorothiazide-telmisartan and Metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c and adjust antidiabetic therapy as needed. Check renal function regularly and reassess metformin if eGFR falls or dehydration occurs.
What other medicines interact with Hydrochlorothiazide-telmisartan?
MediHelp also lists interactions of Hydrochlorothiazide-telmisartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-telmisartan page.
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