Drug interactions
Hydrochlorothiazide-telmisartan + Methyclothiazide
Severity: Major
Hydrochlorothiazide-telmisartan and Methyclothiazide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both products contain thiazide diuretics (hydrochlorothiazide and methyclothiazide), so this is therapeutic duplication. It increases the risk of excessive diuresis, hypotension, hyponatremia, hypokalemia and renal impairment without added benefit.
What this interaction means in plain words
Hydrochlorothiazide-telmisartan and Methyclothiazide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Duplicate thiazide diuretic action at the distal tubule giving additive sodium, potassium and water loss.
What to do
Avoid using two thiazides together and choose a single agent. If a second diuretic is needed, use a different class and monitor electrolytes and renal function.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Hydrochlorothiazide-telmisartan
- Aliskiren + Hydrochlorothiazide-telmisartan Contraindicated
- Dofetilide + Hydrochlorothiazide-telmisartan Contraindicated
- Hydrochlorothiazide-telmisartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-telmisartan Major
- Amifostine + Hydrochlorothiazide-telmisartan Major
- Amiloride + Hydrochlorothiazide-telmisartan Major
Frequently asked questions
Can I take Hydrochlorothiazide-telmisartan with Methyclothiazide?
MediHelp rates the interaction as major. Hydrochlorothiazide-telmisartan and Methyclothiazide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both products contain thiazide diuretics (hydrochlorothiazide and methyclothiazide), so this is therapeutic duplication. It increases the risk of excessive diuresis, hypotension, hyponatremia, hypokalemia and renal impairment without added benefit.
How serious is the interaction between Hydrochlorothiazide-telmisartan and Methyclothiazide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using two thiazides together and choose a single agent. If a second diuretic is needed, use a different class and monitor electrolytes and renal function.
What other medicines interact with Hydrochlorothiazide-telmisartan?
MediHelp also lists interactions of Hydrochlorothiazide-telmisartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-telmisartan page.
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