Drug interactions
Hydrochlorothiazide-telmisartan + Olmesartan
Severity: Major
Hydrochlorothiazide-telmisartan and Olmesartan: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Using two angiotensin receptor blockers together offers no proven benefit and increases the risk of hypotension, hyperkalemia and renal impairment.
What this interaction means in plain words
Hydrochlorothiazide-telmisartan and Olmesartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Hydrochlorothiazide-telmisartan belongs to Cardiovascular; Olmesartan belongs to Cardiovascular.
Why it happens
Duplicate AT1 receptor blockade produces additive hypotension, reduced glomerular filtration and potassium retention.
What to do
Avoid concurrent use of two ARBs and consolidate to one agent. If it occurs, monitor potassium, creatinine and blood pressure.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Hydrochlorothiazide-telmisartan
- Aliskiren + Hydrochlorothiazide-telmisartan Contraindicated
- Dofetilide + Hydrochlorothiazide-telmisartan Contraindicated
- Hydrochlorothiazide-telmisartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-telmisartan Major
- Amifostine + Hydrochlorothiazide-telmisartan Major
- Amiloride + Hydrochlorothiazide-telmisartan Major
Other interactions of Olmesartan
- Aliskiren + Olmesartan Contraindicated
- Olmesartan + Sparsentan Contraindicated
- Aldesleukin + Olmesartan Major
- Amifostine + Olmesartan Major
- Amiloride + Olmesartan Major
- Amlodipine-benazepril + Olmesartan Major
Frequently asked questions
Can I take Hydrochlorothiazide-telmisartan with Olmesartan?
MediHelp rates the interaction as major. Hydrochlorothiazide-telmisartan and Olmesartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Using two angiotensin receptor blockers together offers no proven benefit and increases the risk of hypotension, hyperkalemia and renal impairment.
How serious is the interaction between Hydrochlorothiazide-telmisartan and Olmesartan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use of two ARBs and consolidate to one agent. If it occurs, monitor potassium, creatinine and blood pressure.
What other medicines interact with Hydrochlorothiazide-telmisartan?
MediHelp also lists interactions of Hydrochlorothiazide-telmisartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-telmisartan page.
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