Drug interactions
Hydrochlorothiazide-telmisartan + Parecoxib
Severity: Moderate
Hydrochlorothiazide-telmisartan and Parecoxib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Parecoxib, an NSAID prodrug of valdecoxib, can blunt the antihypertensive effect of telmisartan and hydrochlorothiazide. Combining an NSAID with an ARB and diuretic raises the risk of acute kidney injury and hyperkalemia, particularly in volume-depleted or older patients.
What this interaction means in plain words
Hydrochlorothiazide-telmisartan and Parecoxib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
COX-2 inhibition reduces renal prostaglandins, lowering renal perfusion and sodium excretion and impairing glomerular filtration.
What to do
Maintain hydration and use the shortest effective course. Monitor blood pressure, serum creatinine and potassium.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Hydrochlorothiazide-telmisartan and Parecoxib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Hydrochlorothiazide-telmisartan
- Aliskiren + Hydrochlorothiazide-telmisartan Contraindicated
- Dofetilide + Hydrochlorothiazide-telmisartan Contraindicated
- Hydrochlorothiazide-telmisartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-telmisartan Major
- Amifostine + Hydrochlorothiazide-telmisartan Major
- Amiloride + Hydrochlorothiazide-telmisartan Major
Frequently asked questions
Can I take Hydrochlorothiazide-telmisartan with Parecoxib?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-telmisartan and Parecoxib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Parecoxib, an NSAID prodrug of valdecoxib, can blunt the antihypertensive effect of telmisartan and hydrochlorothiazide. Combining an NSAID with an ARB and diuretic raises the risk of acute kidney injury and hyperkalemia, particularly in volume-depleted or older patients.
How serious is the interaction between Hydrochlorothiazide-telmisartan and Parecoxib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Maintain hydration and use the shortest effective course. Monitor blood pressure, serum creatinine and potassium.
What other medicines interact with Hydrochlorothiazide-telmisartan?
MediHelp also lists interactions of Hydrochlorothiazide-telmisartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-telmisartan page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
