Drug interactions
Hydrochlorothiazide-telmisartan + Penicillin vk
Severity: Minor
Hydrochlorothiazide-telmisartan and Penicillin vk: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Penicillin V is eliminated by active tubular secretion, and thiazides may compete for the same organic anion transport pathway. This could modestly raise penicillin concentrations, but the effect is small and penicillin has a wide safety margin.
What this interaction means in plain words
Hydrochlorothiazide-telmisartan and Penicillin vk have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Competition for renal tubular organic anion secretion reduces penicillin clearance.
What to do
No dose adjustment is normally needed. Be aware of the possibility of higher penicillin exposure in patients with severe renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-telmisartan
- Aliskiren + Hydrochlorothiazide-telmisartan Contraindicated
- Dofetilide + Hydrochlorothiazide-telmisartan Contraindicated
- Hydrochlorothiazide-telmisartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-telmisartan Major
- Amifostine + Hydrochlorothiazide-telmisartan Major
- Amiloride + Hydrochlorothiazide-telmisartan Major
Frequently asked questions
Can I take Hydrochlorothiazide-telmisartan with Penicillin vk?
MediHelp rates the interaction as minor. Hydrochlorothiazide-telmisartan and Penicillin vk have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Penicillin V is eliminated by active tubular secretion, and thiazides may compete for the same organic anion transport pathway. This could modestly raise penicillin concentrations, but the effect is small and penicillin has a wide safety margin.
How serious is the interaction between Hydrochlorothiazide-telmisartan and Penicillin vk?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is normally needed. Be aware of the possibility of higher penicillin exposure in patients with severe renal impairment.
What other medicines interact with Hydrochlorothiazide-telmisartan?
MediHelp also lists interactions of Hydrochlorothiazide-telmisartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-telmisartan page.
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