Drug interactions
Hydrochlorothiazide-telmisartan + Pitavastatin
Severity: Minor
Hydrochlorothiazide-telmisartan and Pitavastatin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Telmisartan has been suggested to inhibit OATP1B1, which could raise pitavastatin exposure slightly. Clinically significant myopathy is possible in theory but the effect is expected to be small.
What this interaction means in plain words
Hydrochlorothiazide-telmisartan and Pitavastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrochlorothiazide-telmisartan belongs to Cardiovascular; Pitavastatin belongs to Cardiovascular.
Why it happens
Possible inhibition of hepatic OATP1B1 uptake of pitavastatin by telmisartan.
What to do
No routine dose change is needed. Advise patients to report unexplained muscle pain or weakness.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-telmisartan
- Aliskiren + Hydrochlorothiazide-telmisartan Contraindicated
- Dofetilide + Hydrochlorothiazide-telmisartan Contraindicated
- Hydrochlorothiazide-telmisartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-telmisartan Major
- Amifostine + Hydrochlorothiazide-telmisartan Major
- Amiloride + Hydrochlorothiazide-telmisartan Major
Other interactions of Pitavastatin
- Cyclosporine + Pitavastatin Contraindicated
- Cyclosporin + Pitavastatin Contraindicated
- Erythromycin base + Pitavastatin Major
- Erythromycin ethylsuccinate + Pitavastatin Major
- Erythromycin lactobionate + Pitavastatin Major
- Erythromycin stearate + Pitavastatin Major
Frequently asked questions
Can I take Hydrochlorothiazide-telmisartan with Pitavastatin?
MediHelp rates the interaction as minor. Hydrochlorothiazide-telmisartan and Pitavastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Telmisartan has been suggested to inhibit OATP1B1, which could raise pitavastatin exposure slightly. Clinically significant myopathy is possible in theory but the effect is expected to be small.
How serious is the interaction between Hydrochlorothiazide-telmisartan and Pitavastatin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Advise patients to report unexplained muscle pain or weakness.
What other medicines interact with Hydrochlorothiazide-telmisartan?
MediHelp also lists interactions of Hydrochlorothiazide-telmisartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-telmisartan page.
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