Drug interactions
Hydrochlorothiazide-telmisartan + Salicylates
Severity: Moderate
Hydrochlorothiazide-telmisartan and Salicylates: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Non-acetylated salicylates can have some NSAID-like effects on renal prostaglandins, which may reduce the antihypertensive effect of telmisartan and raise the risk of renal impairment, especially with volume depletion from the thiazide. The effect is less pronounced than with conventional NSAIDs, and high salicylate doses matter more than low ones.
What this interaction means in plain words
Hydrochlorothiazide-telmisartan and Salicylates can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of renal prostaglandin synthesis reduces renal blood flow and sodium excretion, which blunts ARB and diuretic effects and strains renal function.
What to do
Monitor blood pressure, renal function and potassium if regular high-dose salicylates are used, and ensure adequate hydration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Hydrochlorothiazide-telmisartan and Salicylates, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Hydrochlorothiazide-telmisartan
- Aliskiren + Hydrochlorothiazide-telmisartan Contraindicated
- Dofetilide + Hydrochlorothiazide-telmisartan Contraindicated
- Hydrochlorothiazide-telmisartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-telmisartan Major
- Amifostine + Hydrochlorothiazide-telmisartan Major
- Amiloride + Hydrochlorothiazide-telmisartan Major
Frequently asked questions
Can I take Hydrochlorothiazide-telmisartan with Salicylates?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-telmisartan and Salicylates can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Non-acetylated salicylates can have some NSAID-like effects on renal prostaglandins, which may reduce the antihypertensive effect of telmisartan and raise the risk of renal impairment, especially with volume depletion from the thiazide. The effect is less pronounced than with conventional NSAIDs, and high salicylate doses matter more than low ones.
How serious is the interaction between Hydrochlorothiazide-telmisartan and Salicylates?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, renal function and potassium if regular high-dose salicylates are used, and ensure adequate hydration.
What other medicines interact with Hydrochlorothiazide-telmisartan?
MediHelp also lists interactions of Hydrochlorothiazide-telmisartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-telmisartan page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
