Drug interactions
Hydrochlorothiazide-telmisartan + Sodium sulfate / ?magnesium sulfate / potassium chloride
Severity: Moderate
Hydrochlorothiazide-telmisartan and Sodium sulfate / ?magnesium sulfate / potassium chloride: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Osmotic bowel preparations cause fluid loss and electrolyte shifts, and with a thiazide and an ARB the risk of dehydration, hypotension, acute kidney injury and electrolyte-related arrhythmias or seizures increases. Hydrochlorothiazide adds to sodium, potassium and magnesium depletion, and telmisartan reduces renal perfusion under volume depletion.
What this interaction means in plain words
Hydrochlorothiazide-telmisartan and Sodium sulfate / ?magnesium sulfate / potassium chloride can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive volume depletion and electrolyte disturbance from bowel cleansing, diuretic action and impaired renal autoregulation with ARB.
What to do
Consider holding the diuretic-ARB combination on the day of bowel preparation and the day of the procedure. Ensure adequate fluid intake and check electrolytes and renal function in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-telmisartan
- Aliskiren + Hydrochlorothiazide-telmisartan Contraindicated
- Dofetilide + Hydrochlorothiazide-telmisartan Contraindicated
- Hydrochlorothiazide-telmisartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-telmisartan Major
- Amifostine + Hydrochlorothiazide-telmisartan Major
- Amiloride + Hydrochlorothiazide-telmisartan Major
Frequently asked questions
Can I take Hydrochlorothiazide-telmisartan with Sodium sulfate / ?magnesium sulfate / potassium chloride?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-telmisartan and Sodium sulfate / ?magnesium sulfate / potassium chloride can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Osmotic bowel preparations cause fluid loss and electrolyte shifts, and with a thiazide and an ARB the risk of dehydration, hypotension, acute kidney injury and electrolyte-related arrhythmias or seizures increases. Hydrochlorothiazide adds to sodium, potassium and magnesium depletion, and telmisartan reduces renal perfusion under volume depletion.
How serious is the interaction between Hydrochlorothiazide-telmisartan and Sodium sulfate / ?magnesium sulfate / potassium chloride?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider holding the diuretic-ARB combination on the day of bowel preparation and the day of the procedure. Ensure adequate fluid intake and check electrolytes and renal function in high-risk patients.
What other medicines interact with Hydrochlorothiazide-telmisartan?
MediHelp also lists interactions of Hydrochlorothiazide-telmisartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-telmisartan page.
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