Drug interactions
Hydrochlorothiazide-telmisartan + Sodium sulfate / potassium chloride / magnesium sulfate / polyethylene glycol
Severity: Moderate
Hydrochlorothiazide-telmisartan and Sodium sulfate / potassium chloride / magnesium sulfate / polyethylene glycol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bowel preparation causes fluid and electrolyte losses, and thiazide diuretics add to potassium and sodium depletion and volume loss. Together they can cause dehydration, hypokalemia, hyponatremia and reduced renal perfusion, which is a concern when an angiotensin receptor blocker is also taken.
What this interaction means in plain words
Hydrochlorothiazide-telmisartan and Sodium sulfate / potassium chloride / magnesium sulfate / polyethylene glycol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive fluid and electrolyte loss from osmotic catharsis and thiazide-induced renal potassium and sodium wasting, with volume depletion increasing renal risk alongside the ARB.
What to do
Ensure adequate hydration and consider withholding the diuretic and telmisartan on the day of bowel preparation. Check electrolytes and renal function in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-telmisartan
- Aliskiren + Hydrochlorothiazide-telmisartan Contraindicated
- Dofetilide + Hydrochlorothiazide-telmisartan Contraindicated
- Hydrochlorothiazide-telmisartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-telmisartan Major
- Amifostine + Hydrochlorothiazide-telmisartan Major
- Amiloride + Hydrochlorothiazide-telmisartan Major
Frequently asked questions
Can I take Hydrochlorothiazide-telmisartan with Sodium sulfate / potassium chloride / magnesium sulfate / polyethylene glycol?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-telmisartan and Sodium sulfate / potassium chloride / magnesium sulfate / polyethylene glycol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bowel preparation causes fluid and electrolyte losses, and thiazide diuretics add to potassium and sodium depletion and volume loss. Together they can cause dehydration, hypokalemia, hyponatremia and reduced renal perfusion, which is a concern when an angiotensin receptor blocker is also taken.
How serious is the interaction between Hydrochlorothiazide-telmisartan and Sodium sulfate / potassium chloride / magnesium sulfate / polyethylene glycol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ensure adequate hydration and consider withholding the diuretic and telmisartan on the day of bowel preparation. Check electrolytes and renal function in high-risk patients.
What other medicines interact with Hydrochlorothiazide-telmisartan?
MediHelp also lists interactions of Hydrochlorothiazide-telmisartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-telmisartan page.
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