Drug interactions
Hydrochlorothiazide-telmisartan + Sodium sulfate / potassium sulfate / magnesium sulfate
Severity: Moderate
Hydrochlorothiazide-telmisartan and Sodium sulfate / potassium sulfate / magnesium sulfate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulfate-based bowel preparations cause fluid and electrolyte loss, and when taken with a thiazide and an ARB the risk of dehydration, hypotension, acute kidney injury and electrolyte-related arrhythmias or seizures increases. Volume depletion makes renal function dependent on angiotensin II, which telmisartan blocks.
What this interaction means in plain words
Hydrochlorothiazide-telmisartan and Sodium sulfate / potassium sulfate / magnesium sulfate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive volume depletion and electrolyte disturbance from bowel cleansing, diuretic action and impaired renal autoregulation with ARB.
What to do
Consider withholding the diuretic-ARB combination during bowel preparation, ensure good hydration, and check electrolytes and creatinine in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-telmisartan
- Aliskiren + Hydrochlorothiazide-telmisartan Contraindicated
- Dofetilide + Hydrochlorothiazide-telmisartan Contraindicated
- Hydrochlorothiazide-telmisartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-telmisartan Major
- Amifostine + Hydrochlorothiazide-telmisartan Major
- Amiloride + Hydrochlorothiazide-telmisartan Major
Frequently asked questions
Can I take Hydrochlorothiazide-telmisartan with Sodium sulfate / potassium sulfate / magnesium sulfate?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-telmisartan and Sodium sulfate / potassium sulfate / magnesium sulfate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sulfate-based bowel preparations cause fluid and electrolyte loss, and when taken with a thiazide and an ARB the risk of dehydration, hypotension, acute kidney injury and electrolyte-related arrhythmias or seizures increases. Volume depletion makes renal function dependent on angiotensin II, which telmisartan blocks.
How serious is the interaction between Hydrochlorothiazide-telmisartan and Sodium sulfate / potassium sulfate / magnesium sulfate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider withholding the diuretic-ARB combination during bowel preparation, ensure good hydration, and check electrolytes and creatinine in high-risk patients.
What other medicines interact with Hydrochlorothiazide-telmisartan?
MediHelp also lists interactions of Hydrochlorothiazide-telmisartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-telmisartan page.
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