Drug interactions
Hydrochlorothiazide-telmisartan + Sulbactam / durlobactam
Severity: Minor
Hydrochlorothiazide-telmisartan and Sulbactam / durlobactam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulbactam is eliminated partly by renal tubular secretion through organic anion transporters. Telmisartan may inhibit these transporters and raise sulbactam concentrations, although the clinical impact is predicted rather than well documented.
What this interaction means in plain words
Hydrochlorothiazide-telmisartan and Sulbactam / durlobactam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible inhibition of OAT-mediated renal secretion of sulbactam.
What to do
No dose change is usually needed; monitor renal function and for beta-lactam adverse effects in patients with renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Hydrochlorothiazide-telmisartan and Sulbactam / durlobactam, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Hydrochlorothiazide-telmisartan
- Aliskiren + Hydrochlorothiazide-telmisartan Contraindicated
- Dofetilide + Hydrochlorothiazide-telmisartan Contraindicated
- Hydrochlorothiazide-telmisartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-telmisartan Major
- Amifostine + Hydrochlorothiazide-telmisartan Major
- Amiloride + Hydrochlorothiazide-telmisartan Major
Frequently asked questions
Can I take Hydrochlorothiazide-telmisartan with Sulbactam / durlobactam?
MediHelp rates the interaction as minor. Hydrochlorothiazide-telmisartan and Sulbactam / durlobactam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sulbactam is eliminated partly by renal tubular secretion through organic anion transporters. Telmisartan may inhibit these transporters and raise sulbactam concentrations, although the clinical impact is predicted rather than well documented.
How serious is the interaction between Hydrochlorothiazide-telmisartan and Sulbactam / durlobactam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed; monitor renal function and for beta-lactam adverse effects in patients with renal impairment.
What other medicines interact with Hydrochlorothiazide-telmisartan?
MediHelp also lists interactions of Hydrochlorothiazide-telmisartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-telmisartan page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
