Drug interactions
Hydrochlorothiazide-telmisartan + Sulfasalazine
Severity: Minor
Hydrochlorothiazide-telmisartan and Sulfasalazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulfasalazine has little NSAID-like effect on renal prostaglandins, so a meaningful reduction in telmisartan efficacy or renal harm is not well documented. Its main concerns are rare renal and hematologic effects unrelated to this pair, and no established interaction mechanism exists with telmisartan or hydrochlorothiazide.
What this interaction means in plain words
Hydrochlorothiazide-telmisartan and Sulfasalazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
No well-established mechanism; any effect is theoretical.
What to do
No specific action needed beyond routine monitoring of blood pressure and renal function.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-telmisartan
- Aliskiren + Hydrochlorothiazide-telmisartan Contraindicated
- Dofetilide + Hydrochlorothiazide-telmisartan Contraindicated
- Hydrochlorothiazide-telmisartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-telmisartan Major
- Amifostine + Hydrochlorothiazide-telmisartan Major
- Amiloride + Hydrochlorothiazide-telmisartan Major
Frequently asked questions
Can I take Hydrochlorothiazide-telmisartan with Sulfasalazine?
MediHelp rates the interaction as minor. Hydrochlorothiazide-telmisartan and Sulfasalazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sulfasalazine has little NSAID-like effect on renal prostaglandins, so a meaningful reduction in telmisartan efficacy or renal harm is not well documented. Its main concerns are rare renal and hematologic effects unrelated to this pair, and no established interaction mechanism exists with telmisartan or hydrochlorothiazide.
How serious is the interaction between Hydrochlorothiazide-telmisartan and Sulfasalazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action needed beyond routine monitoring of blood pressure and renal function.
What other medicines interact with Hydrochlorothiazide-telmisartan?
MediHelp also lists interactions of Hydrochlorothiazide-telmisartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-telmisartan page.
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