Drug interactions
Hydrochlorothiazide-telmisartan + Synthetic human angiotensin ii
Severity: Moderate
Hydrochlorothiazide-telmisartan and Synthetic human angiotensin ii: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Telmisartan blocks the AT1 receptor through which angiotensin II raises blood pressure, so the pressor response to infused angiotensin II may be reduced. Patients on ARBs may need higher doses of angiotensin II to reach target blood pressure in vasodilatory shock.
What this interaction means in plain words
Hydrochlorothiazide-telmisartan and Synthetic human angiotensin ii can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Competitive antagonism at the angiotensin II type 1 receptor.
What to do
Titrate angiotensin II to blood pressure response and anticipate higher dose requirements in patients taking telmisartan.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-telmisartan
- Aliskiren + Hydrochlorothiazide-telmisartan Contraindicated
- Dofetilide + Hydrochlorothiazide-telmisartan Contraindicated
- Hydrochlorothiazide-telmisartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-telmisartan Major
- Amifostine + Hydrochlorothiazide-telmisartan Major
- Amiloride + Hydrochlorothiazide-telmisartan Major
Frequently asked questions
Can I take Hydrochlorothiazide-telmisartan with Synthetic human angiotensin ii?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-telmisartan and Synthetic human angiotensin ii can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Telmisartan blocks the AT1 receptor through which angiotensin II raises blood pressure, so the pressor response to infused angiotensin II may be reduced. Patients on ARBs may need higher doses of angiotensin II to reach target blood pressure in vasodilatory shock.
How serious is the interaction between Hydrochlorothiazide-telmisartan and Synthetic human angiotensin ii?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate angiotensin II to blood pressure response and anticipate higher dose requirements in patients taking telmisartan.
What other medicines interact with Hydrochlorothiazide-telmisartan?
MediHelp also lists interactions of Hydrochlorothiazide-telmisartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-telmisartan page.
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