Drug interactions
Hydrochlorothiazide-telmisartan + Telmisartan
Severity: Major
Hydrochlorothiazide-telmisartan and Telmisartan: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The combination product already contains telmisartan, so adding telmisartan duplicates the same drug. This increases the risk of hypotension, hyperkalemia and renal impairment.
What this interaction means in plain words
Hydrochlorothiazide-telmisartan and Telmisartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Hydrochlorothiazide-telmisartan belongs to Cardiovascular; Telmisartan belongs to Cardiovascular.
Why it happens
Therapeutic duplication leading to excessive angiotensin II receptor blockade.
What to do
Avoid concurrent use and keep only one telmisartan-containing regimen. If duplication occurred, check blood pressure, potassium and creatinine.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Hydrochlorothiazide-telmisartan
- Aliskiren + Hydrochlorothiazide-telmisartan Contraindicated
- Dofetilide + Hydrochlorothiazide-telmisartan Contraindicated
- Hydrochlorothiazide-telmisartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-telmisartan Major
- Amifostine + Hydrochlorothiazide-telmisartan Major
- Amiloride + Hydrochlorothiazide-telmisartan Major
Other interactions of Telmisartan
- Aliskiren + Telmisartan Contraindicated
- Sparsentan + Telmisartan Contraindicated
- Amifostine + Telmisartan Major
- Amiloride + Telmisartan Major
- Amlodipine-benazepril + Telmisartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Telmisartan Major
Frequently asked questions
Can I take Hydrochlorothiazide-telmisartan with Telmisartan?
MediHelp rates the interaction as major. Hydrochlorothiazide-telmisartan and Telmisartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. The combination product already contains telmisartan, so adding telmisartan duplicates the same drug. This increases the risk of hypotension, hyperkalemia and renal impairment.
How serious is the interaction between Hydrochlorothiazide-telmisartan and Telmisartan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use and keep only one telmisartan-containing regimen. If duplication occurred, check blood pressure, potassium and creatinine.
What other medicines interact with Hydrochlorothiazide-telmisartan?
MediHelp also lists interactions of Hydrochlorothiazide-telmisartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-telmisartan page.
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