Drug interactions
Hydrochlorothiazide-telmisartan + Terbutaline
Severity: Moderate
Hydrochlorothiazide-telmisartan and Terbutaline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Terbutaline promotes potassium shift into cells and hydrochlorothiazide increases urinary potassium loss, so together they can cause clinically significant hypokalemia. Telmisartan partly offsets this by retaining potassium. Hypokalemia may provoke arrhythmias, especially with high-dose or systemic terbutaline.
What this interaction means in plain words
Hydrochlorothiazide-telmisartan and Terbutaline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide-telmisartan belongs to Cardiovascular; Terbutaline belongs to Respiratory.
Why it happens
Beta-2 agonist-driven intracellular potassium shift plus thiazide-induced renal potassium wasting.
What to do
Monitor serum potassium, especially with high-dose nebulised or parenteral terbutaline, and replace potassium as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-telmisartan
- Aliskiren + Hydrochlorothiazide-telmisartan Contraindicated
- Dofetilide + Hydrochlorothiazide-telmisartan Contraindicated
- Hydrochlorothiazide-telmisartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-telmisartan Major
- Amifostine + Hydrochlorothiazide-telmisartan Major
- Amiloride + Hydrochlorothiazide-telmisartan Major
Other interactions of Terbutaline
Frequently asked questions
Can I take Hydrochlorothiazide-telmisartan with Terbutaline?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-telmisartan and Terbutaline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Terbutaline promotes potassium shift into cells and hydrochlorothiazide increases urinary potassium loss, so together they can cause clinically significant hypokalemia. Telmisartan partly offsets this by retaining potassium. Hypokalemia may provoke arrhythmias, especially with high-dose or systemic terbutaline.
How serious is the interaction between Hydrochlorothiazide-telmisartan and Terbutaline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium, especially with high-dose nebulised or parenteral terbutaline, and replace potassium as needed.
What other medicines interact with Hydrochlorothiazide-telmisartan?
MediHelp also lists interactions of Hydrochlorothiazide-telmisartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-telmisartan page.
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