Drug interactions
Hydrochlorothiazide-telmisartan + Umeclidinium bromide / vilanterol inhaled
Severity: Moderate
Hydrochlorothiazide-telmisartan and Umeclidinium bromide / vilanterol inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vilanterol, a beta-agonist, can lower serum potassium and prolong the QT interval, and hydrochlorothiazide also depletes potassium. The combined effect may cause hypokalemia and ECG changes, especially at higher than recommended doses.
What this interaction means in plain words
Hydrochlorothiazide-telmisartan and Umeclidinium bromide / vilanterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Beta-2 agonist-driven intracellular potassium shift added to thiazide renal potassium loss.
What to do
Monitor serum potassium periodically, particularly in patients with cardiac disease or other hypokalemia risks. Correct low potassium and do not exceed the recommended inhaler dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-telmisartan
- Aliskiren + Hydrochlorothiazide-telmisartan Contraindicated
- Dofetilide + Hydrochlorothiazide-telmisartan Contraindicated
- Hydrochlorothiazide-telmisartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-telmisartan Major
- Amifostine + Hydrochlorothiazide-telmisartan Major
- Amiloride + Hydrochlorothiazide-telmisartan Major
Frequently asked questions
Can I take Hydrochlorothiazide-telmisartan with Umeclidinium bromide / vilanterol inhaled?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-telmisartan and Umeclidinium bromide / vilanterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vilanterol, a beta-agonist, can lower serum potassium and prolong the QT interval, and hydrochlorothiazide also depletes potassium. The combined effect may cause hypokalemia and ECG changes, especially at higher than recommended doses.
How serious is the interaction between Hydrochlorothiazide-telmisartan and Umeclidinium bromide / vilanterol inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium periodically, particularly in patients with cardiac disease or other hypokalemia risks. Correct low potassium and do not exceed the recommended inhaler dose.
What other medicines interact with Hydrochlorothiazide-telmisartan?
MediHelp also lists interactions of Hydrochlorothiazide-telmisartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-telmisartan page.
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