Drug interactions
Hydrochlorothiazide-telmisartan + Vilanterol / fluticasone furoate inhaled
Severity: Moderate
Hydrochlorothiazide-telmisartan and Vilanterol / fluticasone furoate inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vilanterol can lower serum potassium and cause ECG changes, and hydrochlorothiazide also promotes potassium loss. The combination may worsen hypokalemia, particularly with high doses or acute illness.
What this interaction means in plain words
Hydrochlorothiazide-telmisartan and Vilanterol / fluticasone furoate inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Beta-2 agonist-induced intracellular potassium shift added to thiazide renal potassium wasting.
What to do
Monitor serum potassium in patients with additional risk factors and correct deficits. Keep the inhaled dose within the recommended range.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-telmisartan
- Aliskiren + Hydrochlorothiazide-telmisartan Contraindicated
- Dofetilide + Hydrochlorothiazide-telmisartan Contraindicated
- Hydrochlorothiazide-telmisartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-telmisartan Major
- Amifostine + Hydrochlorothiazide-telmisartan Major
- Amiloride + Hydrochlorothiazide-telmisartan Major
Frequently asked questions
Can I take Hydrochlorothiazide-telmisartan with Vilanterol / fluticasone furoate inhaled?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-telmisartan and Vilanterol / fluticasone furoate inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vilanterol can lower serum potassium and cause ECG changes, and hydrochlorothiazide also promotes potassium loss. The combination may worsen hypokalemia, particularly with high doses or acute illness.
How serious is the interaction between Hydrochlorothiazide-telmisartan and Vilanterol / fluticasone furoate inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium in patients with additional risk factors and correct deficits. Keep the inhaled dose within the recommended range.
What other medicines interact with Hydrochlorothiazide-telmisartan?
MediHelp also lists interactions of Hydrochlorothiazide-telmisartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-telmisartan page.
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