Drug interactions
Hydrochlorothiazide-telmisartan + Xipamide
Severity: Moderate
Hydrochlorothiazide-telmisartan and Xipamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Xipamide is a thiazide-like diuretic, so adding it to a regimen that already contains hydrochlorothiazide and telmisartan produces duplicate diuretic therapy and a stronger blood pressure lowering effect. This can lead to volume depletion, hypotension, hyponatremia, hypokalemia and worsening renal function, especially in older or volume-depleted patients.
What this interaction means in plain words
Hydrochlorothiazide-telmisartan and Xipamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic effect from two thiazide-type diuretics acting on the distal tubule, combined with the antihypertensive action of telmisartan.
What to do
Avoid routine combination of two thiazide-type diuretics; if used deliberately, monitor blood pressure, serum sodium, potassium and creatinine within the first weeks. Reduce or stop one diuretic if hypotension or electrolyte disturbance develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-telmisartan
- Aliskiren + Hydrochlorothiazide-telmisartan Contraindicated
- Dofetilide + Hydrochlorothiazide-telmisartan Contraindicated
- Hydrochlorothiazide-telmisartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-telmisartan Major
- Amifostine + Hydrochlorothiazide-telmisartan Major
- Amiloride + Hydrochlorothiazide-telmisartan Major
Frequently asked questions
Can I take Hydrochlorothiazide-telmisartan with Xipamide?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-telmisartan and Xipamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Xipamide is a thiazide-like diuretic, so adding it to a regimen that already contains hydrochlorothiazide and telmisartan produces duplicate diuretic therapy and a stronger blood pressure lowering effect. This can lead to volume depletion, hypotension, hyponatremia, hypokalemia and worsening renal function, especially in older or volume-depleted patients.
How serious is the interaction between Hydrochlorothiazide-telmisartan and Xipamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid routine combination of two thiazide-type diuretics; if used deliberately, monitor blood pressure, serum sodium, potassium and creatinine within the first weeks. Reduce or stop one diuretic if hypotension or electrolyte disturbance develops.
What other medicines interact with Hydrochlorothiazide-telmisartan?
MediHelp also lists interactions of Hydrochlorothiazide-telmisartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-telmisartan page.
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