Drug interactions
Hydrochlorothiazide-valsartan + Indacaterol inhaled
Severity: Moderate
Hydrochlorothiazide-valsartan and Indacaterol inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Beta-agonists and thiazide diuretics both lower serum potassium. Together they may cause additive hypokalemia, which can predispose to arrhythmias, particularly with hypoxia or other QT-prolonging drugs.
What this interaction means in plain words
Hydrochlorothiazide-valsartan and Indacaterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Beta-2 stimulation drives potassium into cells while the thiazide increases renal potassium loss, producing additive hypokalemia.
What to do
Monitor serum potassium and magnesium, especially at initiation and in patients with cardiac disease. Correct hypokalemia before and during therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-valsartan
- Aliskiren + Hydrochlorothiazide-valsartan Contraindicated
- Dofetilide + Hydrochlorothiazide-valsartan Contraindicated
- Hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-valsartan Major
- Amifostine + Hydrochlorothiazide-valsartan Major
- Amiloride + Hydrochlorothiazide-valsartan Major
Frequently asked questions
Can I take Hydrochlorothiazide-valsartan with Indacaterol inhaled?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-valsartan and Indacaterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Beta-agonists and thiazide diuretics both lower serum potassium. Together they may cause additive hypokalemia, which can predispose to arrhythmias, particularly with hypoxia or other QT-prolonging drugs.
How serious is the interaction between Hydrochlorothiazide-valsartan and Indacaterol inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and magnesium, especially at initiation and in patients with cardiac disease. Correct hypokalemia before and during therapy.
What other medicines interact with Hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-valsartan page.
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