Drug interactions
Hydrochlorothiazide-valsartan + Indapamide
Severity: Moderate
Hydrochlorothiazide-valsartan and Indapamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indapamide is a thiazide-like diuretic, so combining it with a product that already contains hydrochlorothiazide duplicates therapy and raises the risk of hypotension, hyponatremia, hypokalemia and renal impairment. Valsartan partly offsets potassium loss but not reliably.
What this interaction means in plain words
Hydrochlorothiazide-valsartan and Indapamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide-valsartan belongs to Cardiovascular; Indapamide belongs to Cardiovascular.
Why it happens
Additive thiazide-type inhibition of the distal tubule sodium-chloride cotransporter, increasing sodium and potassium excretion.
What to do
Avoid concurrent use of two thiazide-type diuretics unless specifically intended. If used, monitor sodium, potassium, creatinine and blood pressure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Hydrochlorothiazide-valsartan and Indapamide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Hydrochlorothiazide-valsartan
- Aliskiren + Hydrochlorothiazide-valsartan Contraindicated
- Dofetilide + Hydrochlorothiazide-valsartan Contraindicated
- Hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-valsartan Major
- Amifostine + Hydrochlorothiazide-valsartan Major
- Amiloride + Hydrochlorothiazide-valsartan Major
Other interactions of Indapamide
Frequently asked questions
Can I take Hydrochlorothiazide-valsartan with Indapamide?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-valsartan and Indapamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indapamide is a thiazide-like diuretic, so combining it with a product that already contains hydrochlorothiazide duplicates therapy and raises the risk of hypotension, hyponatremia, hypokalemia and renal impairment. Valsartan partly offsets potassium loss but not reliably.
How serious is the interaction between Hydrochlorothiazide-valsartan and Indapamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use of two thiazide-type diuretics unless specifically intended. If used, monitor sodium, potassium, creatinine and blood pressure.
What other medicines interact with Hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-valsartan page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
