Drug interactions
Hydrochlorothiazide-valsartan + Indinavir
Severity: Minor
Hydrochlorothiazide-valsartan and Indinavir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Valsartan is a substrate of hepatic uptake transporters OATP1B1 and efflux transporter MRP2, so inhibitors may raise its exposure. Indinavir may modestly raise valsartan levels, with possible increased hypotension. The clinical significance is likely small.
What this interaction means in plain words
Hydrochlorothiazide-valsartan and Indinavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible inhibition of OATP1B1-mediated hepatic uptake of valsartan by indinavir.
What to do
No dose change is usually needed; monitor blood pressure when starting or stopping indinavir.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-valsartan
- Aliskiren + Hydrochlorothiazide-valsartan Contraindicated
- Dofetilide + Hydrochlorothiazide-valsartan Contraindicated
- Hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-valsartan Major
- Amifostine + Hydrochlorothiazide-valsartan Major
- Amiloride + Hydrochlorothiazide-valsartan Major
Frequently asked questions
Can I take Hydrochlorothiazide-valsartan with Indinavir?
MediHelp rates the interaction as minor. Hydrochlorothiazide-valsartan and Indinavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Valsartan is a substrate of hepatic uptake transporters OATP1B1 and efflux transporter MRP2, so inhibitors may raise its exposure. Indinavir may modestly raise valsartan levels, with possible increased hypotension. The clinical significance is likely small.
How serious is the interaction between Hydrochlorothiazide-valsartan and Indinavir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed; monitor blood pressure when starting or stopping indinavir.
What other medicines interact with Hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-valsartan page.
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