Drug interactions
Hydrochlorothiazide-valsartan + Insulin aspart protamine / insulin aspart
Severity: Moderate
Hydrochlorothiazide-valsartan and Insulin aspart protamine / insulin aspart: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Angiotensin receptor blockers may improve insulin sensitivity and enhance the glucose-lowering effect of insulin. Hypoglycemia may occur more often. Thiazide in the combination product may oppose this by raising glucose.
What this interaction means in plain words
Hydrochlorothiazide-valsartan and Insulin aspart protamine / insulin aspart can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
ARBs may enhance insulin sensitivity and glucose uptake, adding to insulin's hypoglycemic effect, while the thiazide can impair glucose tolerance.
What to do
Monitor blood glucose more often after starting or changing the combination, and adjust the insulin dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-valsartan
- Aliskiren + Hydrochlorothiazide-valsartan Contraindicated
- Dofetilide + Hydrochlorothiazide-valsartan Contraindicated
- Hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-valsartan Major
- Amifostine + Hydrochlorothiazide-valsartan Major
- Amiloride + Hydrochlorothiazide-valsartan Major
Frequently asked questions
Can I take Hydrochlorothiazide-valsartan with Insulin aspart protamine / insulin aspart?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-valsartan and Insulin aspart protamine / insulin aspart can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Angiotensin receptor blockers may improve insulin sensitivity and enhance the glucose-lowering effect of insulin. Hypoglycemia may occur more often. Thiazide in the combination product may oppose this by raising glucose.
How serious is the interaction between Hydrochlorothiazide-valsartan and Insulin aspart protamine / insulin aspart?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more often after starting or changing the combination, and adjust the insulin dose as needed.
What other medicines interact with Hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-valsartan page.
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