Drug interactions
Hydrochlorothiazide-valsartan + Insulin detemir
Severity: Moderate
Hydrochlorothiazide-valsartan and Insulin detemir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Valsartan may improve insulin sensitivity and modestly increase the glucose-lowering effect of insulin, with a risk of hypoglycemia. The thiazide component can work in the opposite direction by worsening glucose tolerance.
What this interaction means in plain words
Hydrochlorothiazide-valsartan and Insulin detemir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide-valsartan belongs to Cardiovascular; Insulin detemir belongs to Endocrine.
Why it happens
Angiotensin receptor blockade may improve insulin sensitivity, while thiazides can reduce insulin sensitivity and secretion, giving opposing pharmacodynamic effects.
What to do
Monitor blood glucose more frequently when starting or changing the combination, and adjust the insulin dose if hypoglycemia or hyperglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-valsartan
- Aliskiren + Hydrochlorothiazide-valsartan Contraindicated
- Dofetilide + Hydrochlorothiazide-valsartan Contraindicated
- Hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-valsartan Major
- Amifostine + Hydrochlorothiazide-valsartan Major
- Amiloride + Hydrochlorothiazide-valsartan Major
Other interactions of Insulin detemir
Frequently asked questions
Can I take Hydrochlorothiazide-valsartan with Insulin detemir?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-valsartan and Insulin detemir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Valsartan may improve insulin sensitivity and modestly increase the glucose-lowering effect of insulin, with a risk of hypoglycemia. The thiazide component can work in the opposite direction by worsening glucose tolerance.
How serious is the interaction between Hydrochlorothiazide-valsartan and Insulin detemir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently when starting or changing the combination, and adjust the insulin dose if hypoglycemia or hyperglycemia occurs.
What other medicines interact with Hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-valsartan page.
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