Drug interactions
Hydrochlorothiazide-valsartan + Insulin inhaled
Severity: Moderate
Hydrochlorothiazide-valsartan and Insulin inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics can raise blood glucose and reduce the effectiveness of insulin in patients with diabetes. Valsartan may enhance insulin sensitivity, so glucose changes can go in either direction.
What this interaction means in plain words
Hydrochlorothiazide-valsartan and Insulin inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Thiazide-induced hypokalemia and reduced insulin sensitivity impair glucose control, while ARBs may improve insulin sensitivity.
What to do
Monitor blood glucose and adjust insulin dose when starting or changing the combination; check potassium periodically.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-valsartan
- Aliskiren + Hydrochlorothiazide-valsartan Contraindicated
- Dofetilide + Hydrochlorothiazide-valsartan Contraindicated
- Hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-valsartan Major
- Amifostine + Hydrochlorothiazide-valsartan Major
- Amiloride + Hydrochlorothiazide-valsartan Major
Frequently asked questions
Can I take Hydrochlorothiazide-valsartan with Insulin inhaled?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-valsartan and Insulin inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazide diuretics can raise blood glucose and reduce the effectiveness of insulin in patients with diabetes. Valsartan may enhance insulin sensitivity, so glucose changes can go in either direction.
How serious is the interaction between Hydrochlorothiazide-valsartan and Insulin inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and adjust insulin dose when starting or changing the combination; check potassium periodically.
What other medicines interact with Hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-valsartan page.
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