Drug interactions
Hydrochlorothiazide-valsartan + Insulin lispro protamine / insulin lispro
Severity: Moderate
Hydrochlorothiazide-valsartan and Insulin lispro protamine / insulin lispro: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Angiotensin receptor blockers may enhance insulin sensitivity and increase the risk of hypoglycemia in insulin-treated patients. The thiazide component may oppose this by raising glucose.
What this interaction means in plain words
Hydrochlorothiazide-valsartan and Insulin lispro protamine / insulin lispro can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
ARBs may improve insulin sensitivity, adding to insulin's effect, while thiazides impair glucose tolerance.
What to do
Monitor blood glucose more frequently after starting the combination and adjust insulin dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-valsartan
- Aliskiren + Hydrochlorothiazide-valsartan Contraindicated
- Dofetilide + Hydrochlorothiazide-valsartan Contraindicated
- Hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-valsartan Major
- Amifostine + Hydrochlorothiazide-valsartan Major
- Amiloride + Hydrochlorothiazide-valsartan Major
Frequently asked questions
Can I take Hydrochlorothiazide-valsartan with Insulin lispro protamine / insulin lispro?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-valsartan and Insulin lispro protamine / insulin lispro can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Angiotensin receptor blockers may enhance insulin sensitivity and increase the risk of hypoglycemia in insulin-treated patients. The thiazide component may oppose this by raising glucose.
How serious is the interaction between Hydrochlorothiazide-valsartan and Insulin lispro protamine / insulin lispro?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently after starting the combination and adjust insulin dose as needed.
What other medicines interact with Hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-valsartan page.
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