Drug interactions
Hydrochlorothiazide-valsartan + Levalbuterol
Severity: Moderate
Hydrochlorothiazide-valsartan and Levalbuterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levalbuterol and hydrochlorothiazide can both lower serum potassium. Combined use may lead to clinically significant hypokalemia and arrhythmias, particularly at high bronchodilator doses.
What this interaction means in plain words
Hydrochlorothiazide-valsartan and Levalbuterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Beta-2 agonist intracellular potassium shift adds to thiazide-induced renal potassium loss.
What to do
Monitor serum potassium and magnesium, particularly with frequent or high-dose levalbuterol, and replace potassium if low.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-valsartan
- Aliskiren + Hydrochlorothiazide-valsartan Contraindicated
- Dofetilide + Hydrochlorothiazide-valsartan Contraindicated
- Hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-valsartan Major
- Amifostine + Hydrochlorothiazide-valsartan Major
- Amiloride + Hydrochlorothiazide-valsartan Major
Frequently asked questions
Can I take Hydrochlorothiazide-valsartan with Levalbuterol?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-valsartan and Levalbuterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levalbuterol and hydrochlorothiazide can both lower serum potassium. Combined use may lead to clinically significant hypokalemia and arrhythmias, particularly at high bronchodilator doses.
How serious is the interaction between Hydrochlorothiazide-valsartan and Levalbuterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and magnesium, particularly with frequent or high-dose levalbuterol, and replace potassium if low.
What other medicines interact with Hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-valsartan page.
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