Drug interactions
Hydrochlorothiazide-valsartan + Maitake
Severity: Minor
Hydrochlorothiazide-valsartan and Maitake: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Maitake mushroom has been reported to lower blood pressure in animal studies and may add to the effects of antihypertensives. Human evidence is lacking and the interaction is largely theoretical.
What this interaction means in plain words
Hydrochlorothiazide-valsartan and Maitake have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive blood pressure lowering; the mechanism is not well established.
What to do
Monitor blood pressure if maitake supplements are started or stopped.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-valsartan
- Aliskiren + Hydrochlorothiazide-valsartan Contraindicated
- Dofetilide + Hydrochlorothiazide-valsartan Contraindicated
- Hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-valsartan Major
- Amifostine + Hydrochlorothiazide-valsartan Major
- Amiloride + Hydrochlorothiazide-valsartan Major
Frequently asked questions
Can I take Hydrochlorothiazide-valsartan with Maitake?
MediHelp rates the interaction as minor. Hydrochlorothiazide-valsartan and Maitake have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Maitake mushroom has been reported to lower blood pressure in animal studies and may add to the effects of antihypertensives. Human evidence is lacking and the interaction is largely theoretical.
How serious is the interaction between Hydrochlorothiazide-valsartan and Maitake?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure if maitake supplements are started or stopped.
What other medicines interact with Hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-valsartan page.
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