Drug interactions
Hydrochlorothiazide-valsartan + Methotrexate
Severity: Moderate
Hydrochlorothiazide-valsartan and Methotrexate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics may reduce renal elimination of methotrexate and have been reported to increase its myelosuppressive effect. The risk is greater with higher methotrexate doses or impaired renal function.
What this interaction means in plain words
Hydrochlorothiazide-valsartan and Methotrexate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide-valsartan belongs to Cardiovascular; Methotrexate belongs to Oncology.
Why it happens
Reduced renal tubular clearance of methotrexate, possibly with diuretic-related volume depletion lowering renal function.
What to do
Monitor complete blood counts and renal function, and watch for signs of methotrexate toxicity; consider dose reduction with high-dose methotrexate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-valsartan
- Aliskiren + Hydrochlorothiazide-valsartan Contraindicated
- Dofetilide + Hydrochlorothiazide-valsartan Contraindicated
- Hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-valsartan Major
- Amifostine + Hydrochlorothiazide-valsartan Major
- Amiloride + Hydrochlorothiazide-valsartan Major
Other interactions of Methotrexate
- Acitretin + Methotrexate Contraindicated
- Adenovirus types 4 and 7 live + Methotrexate Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Methotrexate Contraindicated
- Ketorolac + Methotrexate Contraindicated
- Measles mumps and rubella vaccine live + Methotrexate Contraindicated
- Measles mumps and rubella vaccine + Methotrexate Contraindicated
Frequently asked questions
Can I take Hydrochlorothiazide-valsartan with Methotrexate?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-valsartan and Methotrexate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazide diuretics may reduce renal elimination of methotrexate and have been reported to increase its myelosuppressive effect. The risk is greater with higher methotrexate doses or impaired renal function.
How serious is the interaction between Hydrochlorothiazide-valsartan and Methotrexate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts and renal function, and watch for signs of methotrexate toxicity; consider dose reduction with high-dose methotrexate.
What other medicines interact with Hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-valsartan page.
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